Andy Robinson has made four changes including one positional switch to the Scotland side aiming to inflict a first defeat on England in the 2011 RBS 6 Nations.
Wing Simon Danielli, centre Joe Ansbro and scrum-half Rory Lawson all come into the starting XV while Nathan Hines returns at blind-side.
Lion Mike Blair and Nick De Luca drop to the bench, where flanker Alasdair Strokosch returns for the first time this season.
Test rookie Ruaridh Jackson is retained at fly-half at the expense of Dan Parks, having made his first start against Ireland, while Sean Lamont continues at inside centre.
Sunday's clash marks the 100th anniversary of Scotland's first trip to Twickenham, but in 44 matches they have won just four times, the last time in 1983.
Robinson coached England to victory over Scotland in 2005 but tasted defeat at Murrayfield the following year.
But the former Lions assistant coach reckons Scotland are more than capable of throwing the record book out to window.
"The record books show what a special achievement it would be for the Scotland team to win on Sunday," said
Robinson.
"That is our intention and we firmly believe that if we can deliver a sustained, intelligent and ruthless performance then we can achieve our first win of this season's championship.
"England have played some good rugby in this championship but Sunday is about our performance.
"Simon Danielli and Rory Lawson have both been playing well for their clubs and Joe Ansbro was unfortunate to miss the game against Ireland through injury, while Nathan Hines' experience will be an asset for us in our back row."
Scotland boast two former Lions in their starting XV namely Ross Ford and Nathan Hines while fellow tourist Mike Blair is named among the replacements.
Paterson; Danielli, Ansbro, S Lamont, M Evans; Jackson, R Lawson; Jacobsen , Ford , Low, Gray, Kellock (capt), Hines, Barclay, Brown.
