The 28-year-old, who toured Australia in 2013 and New Zealand two years ago, suffered the injury in training and requires surgery, with no timeframe put on his return.
It is the latest frustration for the No.8, who has not played Test rugby since March 2018. A broken arm ruined his campaign last season and forced him to miss Wales’ Six Nations Grand Slam.
A statement by the Welsh Rugby Union said: “The injury was sustained in an innocuous training ground incident and will require surgery.
SQUAD UPDATE: Taulupe Faletau has been ruled out of Rugby World Cup contention due to a clavicle injury. Dymuniadau gorau i Taulupe oddi wrth y garfan i gyd.
📰 – https://t.co/E7ms6WBM5n pic.twitter.com/9nRSKNXE08
— Welsh Rugby Union 🏉 (@WelshRugbyUnion) August 1, 2019
“A prognosis and return to play timeframe will be established after surgery.
“The Wales squad and management would like to wish Taulupe the very best with his recovery.”
Wales face Australia, Georgia, Fiji and Uruguay in Pool D.