The only try of the match, Warren Gatland’s men enacted revenge over their rivals after England had dealt them a 33-19 defeat at Twickenham.
A tight affair throughout, Wales showed impressive resolve when England asked questions in the second half, digging in to get back to winning ways.
After half an hour of defences holding firm, the game burst into life in the space of 60 seconds.
Anthony Watson, 2017 Lions British & Irish Lions tourist, was shown yellow for a deliberate knock on, and as he trudged off Wales demonstrated exceptionally quick thinking to send a lofted kick downfield.
The hosts had caught England cold, Josh Adams gathering before recycled ball found Dan Biggar, who guided a cross-kick over to two-time tourist North in acres of space to dot down for the first try of the game.
Ten down at the break, England dug in to steady the ship and respond early in the second half; George Ford slotting a pair of penalties to get them on the board and within four.
England tested Welsh nerves when a Jamie George-led break saw Watson charge for the line, but danger was averted brilliantly as the hosts looked to hold out.
Leigh Halfpenny, after missing a long-ranger, slotted his second chance from distance off the tee, giving England work to do in the final five minutes.
But they could not find the crucial score, leaving the hosts to toast a triumph that hauls them above all others in the international game.